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The compatibility of 5-fluorouracil (5-FU) with Parenteral Nutrient (PN) solution during simulated Y-site administration was studied. Five mililiter of representative PN solution was combined in duplicate in a 1:1 ratio with 5 ㎖ sample of solution of 5-FU in 5% dextrose injection (25, 50, 75, 100 ㎎/㎗). Chemical compatibility was examined the HPLC. The test was performed at intervals up to fourteen hours ; storage was at room temperature. Physical compatibility was performed for nonsoluble particle sizing and counting. All evaluations were performed at intervals up to six hours. The test group result of HPLC test were reduced 7.9, 7.6, 4.5, 7.9% in the 25, 50, 75, 100 ㎎/㎗. The blind group test were reduced 10.6, 8.7, 6.5, 5.8% in the 25, 50, 75, 100 ㎎/㎗. The result of nonsoluble particle sizing and counting were suitable for KSP criteria. During simulated Y-site administration, PN solution was compatible with 5-FU solution.
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